eHealth and Wellbeing are emergent and cross-domain topics, which have gained particular attention during the current pandemic scenario. An enriched vision of the role of Digital Media in these areas can be deepened with the contribution of this Special Issue that aims at presenting, from a technological, communicational and societal perspective, innovative digital media solutions to improve health, wellbeing, quality-of-life, accessibility and active ageing, acknowledging the role of digital inclusion and the diversity of populations and health conditions that frame this topic