Impacto do Treino Cognitivo Computadorizado em Adultos com Depressão Moderada a Grave: Um estudo piloto

(Impact of Computerized Cognitive Training on Adults with Moderate to Severe Depression: Apilot study)

  • Ana Malta Mestre em Psicologia da Saude e Reabilitação Neuropsicológica UA
  • Óscar Ribeiro
Keywords: depression, cognitive training, attention, memory, executive functions

Abstract

As principais alterações cognitivaspresentes nas perturbações depressivasocorrem ao nível da memória, atenção e funções executivas. Vários estudos revelam que os défices cognitivos tendem a permanecer após a remissão de outros sintomas depressivos. Investigação recente tem sugerido que o treino cognitivo computadorizado (TCC) poderá ser uma opção de tratamento eficaz, pois as intervenções que utilizam a tecnologia parecem demonstrar mais benefícios na estimulação das funções cognitivas e qualidade de vida comparativamente a programas tradicionais.Este artigo apresenta um estudo piloto que avaliao impacto de umTCC com recurso ao COGWEB® em pacientes com depressão moderada a grave (n=20). Destina-se, assim, a avaliar o efeito do TCC no humor (severidade de sintomatologia depressiva) e num conjunto de funções cognitivas (atenção, memória e funcionamento executivo).Os pacientes foram divididos entre um grupo experimental, que realizou duas sessões de treino cognitivo por semana (total de 12 sessões), e um grupo de controlo, sem treino cognitivo. Ambos realizaram pré e pós teste (antese depois da intervenção), onde foram aplicados o Inventário de Depressão de Beck e uma bateria de testes neuropsicológicos (Montreal Cognitive Assessment, Trilhas A e B, Teste do Relógio, Teste de Stroop e Auditory Verbal Learning Test).Concluiu-se que os pacientes que realizaram o TCC apresentaram uma melhoria na sintomatologia depressiva e alterações positivas em todas funções cognitivas avaliadas, comparativamente ao grupo de pacientes que não foi submetido a este treino cognitivoeque, no pós-teste, apresentou piores resultados nos domínios cognitivos avaliados.

(The major cognitive domains that present changes in depressive disorders include memory, attention, and executive functions. Several studies have shown that cognitive deficits tend to remain after the remission of other depressive symptoms. Recent research has suggested that computerized cognitive training (CCT) may be an effective treatment option since interventions using technology seem to show more benefits in stimulating cognitive functions and quality of life when compared to traditional training programs. This pilot study evaluates the impact of a CCT using COGWEB® in patients with moderate to severe depression (n=20), namely on humor (severity of depressive symptoms) and on a set of cognitive functions (attention, memory and executive function). A sample of clinical patients was divided into an experimental group, who performed two cognitive training sessions per week (a total of 12 sessions), and a control group, who received no cognitive training. Both groups underwent a pre- and post-test (before and after the intervention) that included the Beck Depression Inventory and a battery of neuropsychological tests (Montreal Cognitive Assessment, Trail Making Test A and B, Clock Drawing Test, Stroop Color and Word Test, and Auditory Verbal Learning Test). In general, the patients who received CCT showed an improvement in depressive symptoms and positive changes in all cognitive functions under analysis when compared to the group of patients who did not receive the cognitive computer training – these, in the post-test, presented worse results in all the evaluated domains.)

Downloads

Download data is not yet available.

References

Ahern, E., & Semkovska, M. (2017). Cognitive functioning in the first-episode of major depressive disorder: A systematic reviewand meta-analysis. Neuropsychology, 31(1), 52–72. https://doi.org/10.1037/neu0000319

Alvarez, L. M., Cortés Sotres, J. F., León, S. O., Estrella, J., & Sánchez Sosa, J. J. (2008). Computer program in the treatment for major depression and cognitive impairment in university students. Computers in Human Behavior, 24(3), 816–826. https://doi.org/10.1016/j.chb.2007.02.013

Avila, R., & Bottino, C. M. D. C. (2006). Cognitive changes update among elderly with depressive syndrome. Revista Brasileira de Psiquiatria, 28(4), 316–320. https://doi.org/10.1590/S1516-44462006000700013

Babins, L., Slater, M., Whitehead, V., Chertkow, H., & Chertkow, H. (2008). Can an 18-point clock-drawing scoring system predict dementia in elderly individuals with mild cognitive impairment? Journal of Clinical and Experimental Neuropsychology, 30(2), 173–186. https://doi.org/10.1080/13803390701336411

Baune, B. T., Miller, R., McAfoose, J., Johnson, M., Quirk, F., Mitchell, D., ... Zajecka, J. (2010). The role of cognitive impairment in general functioning in major depression. Psychiatry Research, 176(2–3), 183–189. https://doi.org/10.1016/j.psychres.2008.12.001

Bora, E., Harrison, B. J., Yücel, M., & Pantelis, C. (2013). Cognitive impairment in euthymic major depressive disorder: A meta-analysis. Psychological Medicine, 43(10), 2017–2026. https://doi.org/10.1017/S0033291712002085

Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016). Cognitive remission: A novel objective for the treatment of major depression? BMC Medicine, 14(1), 1–18. https://doi.org/10.1186/s12916-016-0560-3

Calkins, A. W., McMorran, K. E., Siegle, G. J., & Otto, M. W. (2015). The Effects of Computerized Cognitive Control Training on Community Adults with Depressed Mood. Behavioural and Cognitive Psychotherapy, 43(5), 578–589. https://doi.org/10.1017/S1352465814000046

Cavaco, S., Gonçalves, A., Pinto, C., Almeida, E., Gomes, F., Moreira, I., ... Teixeira-pinto, A. (2015). Auditory Verbal Learning Test in a Large Nonclinical Portuguese Population. Applied Neuropsychology: Adult, 0, 1–11. https://doi.org/10.1080/23279095.2014.927767

Cavaco, S., Gonçalves, A., Pinto, C., Almeida, E., Gomes, F., Moreira, I., ... Teixeira-Pinto, A. (2013). Trail Making Test : Regression-based Norms for the Portuguese Population, 28(January), 189–198. https://doi.org/10.1093/arclin/acs115

Cohen, R., Lohr, I., Paul, R., & Boland, R. (2014). Impairments of Attention and Effort Among Patients With Major Affective Disorders. The Journal of Neuropsychiatry and Clinical Neurosciences, 13(3), 385–395. https://doi.org/10.1176/jnp.13.3.385

Cruz, V. T., Pais, J., Ruano, L., Mateus, C., Colunas, M., Alves, I., ... COGWEB Network Collaborators. (2014). Implementation and Outcomes of a Collaborative Multi-Center Network Aimed at Web-Based Cognitive Training -COGWEB Network. JMIR Mental Health, 1(1), e2. https://doi.org/10.2196/mental.3840

Douglas, K. M., & Porter, R. J. (2009). Longitudinal assessment of neuropsychological function in major depression. Australian and New Zealand Journal of Psychiatry, 43, 1105–1117. Retrieved from http://www.informaworld.com/smpp/content~content=a917603098~db=all~jumptype=rss

Esteves, C. S., Oliveira, C. R., Irigaray, T. Q., & Argimon, I. I. de L. (2017). Desempenho de idosos com e sem sintomas depressivos no WCST-64. Revista Avaliação Psicológica, 15(1), 31–39. https://doi.org/10.15689/ap.2016.1501.04

Faucounau, V., Wu, Y. H., Boulay, M., De Rotrou, J., & Rigaud, A. S. (2010). Cognitive intervention programmes on patients affected by mild cognitive impairment: A promising intervention tool for MCI? Journal of Nutrition, Health and Aging, 14(1), 31–35. https://doi.org/10.1007/s12603-010-0006-0

Freitas, S., Simões, M. R., Martins, C., Vilar, M.,& Santana, I. (2010). Estudos de Adaptação do Montreal Cognitive Assessment (Moca) para a População Portuguesa. Avaliação Psicológica, 9(3), 345–357. Retrieved from http://pepsic.bvsalud.org/pdf/avp/v9n3/v9n3a02.pdf

Freire, T., & Almeida, L. S. (2008). Metodologia da Investigação em Psicologia e Educação (5a edição). Braga: Psiquilíbrios Edições.

Ge, S., Zhu, Z., Wu, B., & McConnell, E. S. (2018). Technology-based cognitive training and rehabilitation interventions for individuals with mild cognitive impairment: A systematic review. BMC Geriatrics, 18(1). https://doi.org/10.1186/s12877-018-0893-1

Golden, C. J., Freshwater, S. M., & Fernandes, S. (2013). STROOP, Teste de cores e palavras (1a edição). Lisboa.

Knight, M. J., & Baune, B. T. (2018). Cognitive dysfunction in major depressive disorder. Current Opinion in Psychiatry, 31(1), 26–31. https://doi.org/10.1097/YCO.0000000000000378

Lee, R. S. C., Hermens, D. F., Porter, M. A., & Redoblado-Hodge, M. A. (2012). A meta-analysis of cognitive deficits in first-episode Major Depressive Disorder. Journal of Affective Disorders, 140(2), 113–124. https://doi.org/10.1016/j.jad.2011.10.023

Luna, F. B. (1998). Sequência Básica na Elaboração de Protocolos de Pesquisa. Arquivo Brasileiro de Cardiologia, 71(6), 735–740.

McClintock, S. M., Husain, M. M., Greer, T. L., & Cullum, C. M. (2010). Association between depression severity and neurocognitive function in major depressive disorder: A review and synthesis. Neuropsychology, 24(1), 9–34. https://doi.org/10.1037/a0017336

Motter, J. N., Pimontel, M. A., Rindskopf, D., Devanand, D. P., Doraiswamy, P. M., & Sneed, J. R. (2016). Computerized cognitive training and functional recovery in major depressive disorder: A meta-analysis. Journal of Affective Disorders, 189, 184–191. https://doi.org/10.1016/j.jad.2015.09.022

Paelecke-Habermann, Y., Pohl, J., & Leplow, B. (2005). Attention and executive functions in remitted major depression patients. Journal of Affective Disorders, 89(1–3), 125–135. https://doi.org/10.1016/j.jad.2005.09.006

Piovesan, A., & Temporini, E. R. (1995). Pesquisa exploratória : procedimento metodológico para o estudo de fatores humanos no campo da saúde pública. Revista de Saúde Pública, 29(4), 318–325. https://doi.org/10.1590/s0034-89101995000400010

Prado, C. E., Watt, S., & Crowe, S. F. (2018). A meta-analysis of the effectsof antidepressants on cognitive functioning in depressed and non-depressed samples. Neuropsychology Review, 28(1), 32–72. https://doi.org/10.1007/s11065-018-9369-5

Roca, M., Vives, M., López-navarro, E., García-campayo, J., & Gili, M. (2015). Cognitive impairments and depression: a critical review. Actas Esp Psiquiatr, 43(5), 187–193.

Rock, P. L., Roiser, J. P., Riedel, W. J., & Blackwell, A. D. (2014). Cognitive impairment in depression : a systematic review and meta-analysis. Psychological Medicine, 44, 2029–2040. https://doi.org/10.1017/S0033291713002535

Santana, I., Duro, D., Freitas, S., Alves, L., & Simões, M. (2013). The Clock Drawing Test : Portuguese Norms , by Age and Education , for Three Different Scoring Systems. Archives of Clinical Neuropsychology, 28, 375–387. https://doi.org/10.1093/arclin/act016

Snyder, H. R. (2013). Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: A meta-analysis and review. Psychological Bulletin, 139(1), 81–132. https://doi.org/10.1037/a0028727

Vakil, E., & Blachstein, H. (1993). Rey auditory-verbal learning test: Structure analysis. Journal of Clinical Psychology, 49(6), 883–890. https://doi.org/10.1002/1097-4679(199311)49:6<883::AID-JCLP2270490616>3.0.CO;2-6

Vaz Serra, A. S., & Abreu, J. L. (1973). Aferição dos quadros clínicos depressivos I. –Ensaio de aplicação do “Inventário depressivo de Beck” a uma amostra portuguesa de doentes deprimidos. Separata da Coimbra Médica XX (VII), 623-644.

Zaremba, D., Kalthoff, I. S., Förster, K., Redlich, R., Grotegerd, D., Leehr, E. J., ... Dannlowski, U. (2019). The effects of processing speed on memory impairment in patients with major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry. https://doi.org/10.1016/J.PNPBP.2019.02.015

Published
2020-12-29