Meta-analysis of Chemical exposure and increased risk of hematologic malignancies.
Abstract
Background: Exposure to environmental risk factors may be associated with the development of hematologic malignancies, as pointed by evidence in the literature. Despite this, most studies refer to a specific risk factor or disease.
Objective: To assess this issue globally, in this study we performed a meta-analysis.
Methods: A searched PubMed database was done in 2020 and a selection of 35 case-control and cohort studies published between 1990 and 2020 was done.
Results: Was observed a significant adverse association between exposure to organic solvents such as benzene and incidence of myeloid malignancies. For agricultural chemicals (pesticides, herbicides, insecticides), an adverse association was found for both lymphoid and myeloid malignancies.
Conclusions: The results suggest that activities in chemical industries or agriculture pose greater risk and should be closely monitored. Prospective occupational surveys are needed to identify exposure–response relationships and clarify disease mechanisms.
Copyright (c) 2022 Gisela Ferreira, Vera Afreixo, Adela Iutis, Raquel Silva
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