Role of Endoplasmic Reticulum stress in sensitization induced dendritic-like cell maturation/toxicity

Resumo

The pathogenesis of allergic contact dermatitis, the most common manifestation of immunotoxicity in humans, is intimately connected to hapten-induced maturation of dendritic cells (DC). The molecular mechanisms driving this maturational program are not completely known, however, initial danger signals such as the generation of reactive oxygen species (ROS) were shown to play a critical role.
Recent evidence linking ROS production, endoplasmic reticulum (ER) stress and the pathogenesis of several inflammatory diseases led us to analyze, in the present work, the ability of the skin sensitizer 1-fluoro-2,4dinitrobenzene (DNFB) to evoke ER stress in DC-like THP-1 cells and the concomitant consequences to their immunobiology. [...]