Effects of the human pharmaceutical gemfibrozil on fish Sparus aurata

Ângela Barreto; Luís Luís; Amadeu Soares; Ketil Hylland; Susana Loureiro; Miguel Oliveira

doi:10.34624/captar.v6i1.11983

Ângela Barreto Departament of Biology, University of Aveiro, CESAM, University of Aveiro
Luís Luís Departament of Biology, University of Aveiro
Amadeu Soares Departament of Biology, University of Aveiro, CESAM, University of Aveiro
Ketil Hylland University of Oslo, Norway
Susana Loureiro Departament of Biology, University of Aveiro, CESAM, University of Aveiro
Miguel Oliveira Departament of Biology, University of Aveiro, CESAM, University of Aveiro,

DOI: https://doi.org/10.34624/captar.v6i1.11983

Resumo

The growing use of pharmaceutical products is becoming a new environmental problem. The occurrence and fate of pharmaceutically active compounds in the aquatic environment has been recognized as one of the emerging issues in environmental chemistry. Blood lipid lowering agents are among the most commonly found drugs in the aquatic environment. Gemfibrozil, one of the most frequently detected pharmaceuticals from this class, may be considered a high priority pharmaceutical on the basis of its consumption, physico-chemical properties, environmental occurrence and persistence. However, little is known about the aquatic toxicity of gemfibrozil. Therefore, short-term exposure of Sparus aurata to dissimilar concentrations of gemfibrozil, including environmentally relevant concentrations was performed and behavioral and biochemical responses were assessed as endpoints.