Comparative study of chronic TLE patients using structural and metabolic MRI measures of hippocampal damage

P. M. Gonçalves Pereira; M. Forjaz Secca; A. Leal; P. Evangelista; C. Ribeiro; P. Rosado

P. M. Gonçalves Pereira Serviço de Neurorradiologia, Hospital de Egas Moniz
M. Forjaz Secca Ressonância Magnética de Caselas, S.D.I. Lisboa; Dpt. de Física, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa
A. Leal Serviço de Neurologia, Hospital de Fernando Fonseca
P. Evangelista Serviço de Neurorradiologia, Hospital de Egas Moniz; Ressonância Magnética de Caselas, S.D.I. Lisboa
C. Ribeiro Serviço de Neurorradiologia, Hospital de Egas Moniz, Lisboa; Ressonância Magnética de Caselas, S.D.I. Lisboa
P. Rosado Serviço de Neurologia, Hospital de Egas Moniz

Resumo

Chemical-shift imaging (CSI) has been applied to the evaluation of patients with temporal lobe epilepsy (TLE), but few comparisons have been made between the data obtained from quantitative structural magnetic resonance imaging (MRI) and the accuracy of CSI to identify pathological changes within the hippocampus. Our goal was to determine the discriminative capability of CSI hippocampal NAA /(Cho+Cre) ratios to distinguish between patients with lateralized epileptic foci when compared to structural MRI measures of disease.