Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

  • Cian J. Lynch Spanish National Cancer Research Centre (CNIO); Institute for Research in Biomedicine (IRB Barcelona), Institute of Science and Technology (BIST)
  • Raquel Bernad Spanish National Cancer Research Centre (CNIO); Institute for Research in Biomedicine (IRB Barcelona), Institute of Science and Technology (BIST)
  • Ana Martínez-Val Spanish National Cancer Research Centre (CNIO)
  • Marta N. Shahbazi Department of Physiology, Development and Neuroscience, University of Cambridge; MRC Laboratory of Molecular Biology
  • Sandrina Nóbrega-Pereira Department of Medical Sciences & iBiMED, University of Aveiro
  • Isabel Calvo Spanish National Cancer Research Centre (CNIO); Institute for Research in Biomedicine (IRB Barcelona), Institute of Science and Technology (BIST)
  • Carmen Blanco-Aparicio Spanish National Cancer Research Centre (CNIO)
  • Carolina Tarantino Institute for Bioengineering of Catalonia (IBEC), BIST
  • Elena Garreta Institute for Bioengineering of Catalonia (IBEC), BIST
  • Laia Richart-Ginés Institut Curie
  • Noelia Alcazar Spanish National Cancer Research Centre (CNIO); Institute for Research in Biomedicine (IRB Barcelona), Institute of Science and Technology (BIST)
  • Osvaldo Graña-Castro Spanish National Cancer Research Centre (CNIO)
  • Gonzalo Gómez-Lopez Spanish National Cancer Research Centre (CNIO)
  • Irene Aksoy Stem Cell and Brain Research Institute, University Lyon
  • Maribel Muñoz-Martín Spanish National Cancer Research Centre (CNIO); Institute for Research in Biomedicine (IRB Barcelona), Institute of Science and Technology (BIST)
  • Sonia Martinez Spanish National Cancer Research Centre (CNIO)
  • Sagrario Ortega Spanish National Cancer Research Centre (CNIO)
  • Susana Prieto IGMM, University of Montpellier
  • Elisabeth Simboeck IGMM, University of Montpellier
  • Alain Camasses IGMM, University of Montpellier
  • Camille Stephan-Otto Attolini Institute for Research in Biomedicine (IRB Barcelona), Institute of Science and Technology (BIST)
  • Agustin F. Fernandez Nanomaterials and Nanotechnology Research Center, Universidad de Oviedo
  • Marta I. Sierra Nanomaterials and Nanotechnology Research Center, Universidad de Oviedo
  • Mario F. Fraga Nanomaterials and Nanotechnology Research Center, Universidad de Oviedo
  • Joaquin Pastor Spanish National Cancer Research Centre (CNIO)
  • Daniel Fisher IGMM, University of Montpellier
  • Nuria Montserrat Institute for Bioengineering of Catalonia (IBEC), BIST; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina; Catalan Institution for Research and Advanced Studies (ICREA)
  • Pierre Savatier Stem Cell and Brain Research Institute, University of Lyon
  • Javier Muñoz Spanish National Cancer Research Centre (CNIO)
  • Magdalena Zernicka-Goetz Department of Physiology, Development and Neuroscience, University of Cambridge; Division of Biology and Biological Engineering, Caltech
  • Manuel Serrano Spanish National Cancer Research Centre (CNIO); Institute for Research in Biomedicine (IRB Barcelona), Institute of Science and Technology (BIST); Catalan Institution for Research and Advanced Studies (ICREA)

Abstract

No abstract available.

Published
2021-06-19
Section
Research highlights